Cleghorn, Blaine

Phone: (902) 494-2448

Email: blaine.cleghorn@dal.ca

Associate Professor, Department of Dental Clinical Sciences, Division of Comprehensive Care

Academic Credentials:
DMD (Manitoba), MS Oral Biology (Manitoba)
Professional Appointments:
Chief Written Examiner, National Dental Examining Board of Canada
Examination Coordinator, North East Regional Board



Research Interests:

Dental caries is a chronic disease among various population groups. Patient care can be improved and health costs reduced by diagnosing caries at the earliest stage. Current diagnostic modalities do not have sufficient sensitivity and specificity. In collaboration with the NRC and the University of Manitoba, we are developing a new diagnostic tool using a combination of two new methods - optical coherence tomography (OCT) and polarized Raman spectroscopy (PRS). OCT produces depth images of near-surface tissue structures with a resolution of greater magnitude than ultrasound imaging. PRS provides biochemical information about the tooth’s mineral content, crystallinity and composition. The combination of OCT and PRS provides a new diagnostic method with both high sensitivity and specificity that will improve early caries detection. Current studies are focused on developing intraoral probes to validate the findings in vivo.

Patents:

Choo-Smith, L-P, Ko, A, Hewko, M, Leonardi, L, Cleghorn, B and Dong, C. 2010. Detection and monitoring changes in mineralized tissues or calcified deposits by optical coherence tomography and Raman spectroscopy. United States. Date of Patent: September 14, 2010. Serial No: US 7,796,243 B2.

Choo-Smith, L-P, Ko, A, Leonardi, L, Hewko, M, Dong, C and Cleghorn, B. 2004. Detection and monitoring changes in mineralized tissues or calcified deposits by optical coherence tomography and Raman spectroscopy. United States. Serial No: 60/578,070.

Research Projects:

Validating OCT and Raman spectroscopy for assessment of tooth de/remineralization.
Funding Agency:NIH - NIDCR
Start Date:2012End Date:2017
Investigator Status:Co-Investigator
Co-Investigators:L-P Choo-Smith (PI), M Alexander, M Hewko, F Kraglund, G Lamouche, M Sowa, M Zhilkin
Developing an Oral Health Clinical Research Enterprise in Nova Scotia
Funding Agency:NSHRF - REDI
Start Date:2012End Date:2013
Investigator Status:Co-Investigator
Co-Investigators:D Boyd (PI), M Filiaggi, RW Loney
Validating OCT and Raman spectroscopy for assessment of tooth de/remineralization.
Funding Agency:National Institutes of Health- National Institute of Dental and Craniofacial Research
Start Date:2006End Date:2010
Investigator Status:Co-Investigator
Co-Investigators:Choo-Smith, L-P, Dawes, C, Dong, C, Hewko, M, Ko, A, Sowa, M, Toppart, P and Wiltshire, W
Improved early diagnosis of dental caries by a novel multi-modal optical tool.
Funding Agency:CIHR Operating Grant
Start Date:2004End Date:2007
Investigator Status:Co-Investigator
Co-Investigators:Choo-Smith, L-P, Leonardi, L, Hewko, M, and Dong, C
Dental caries diagnosis by optical methods.
Funding Agency:Manitoba Medical Services Foundation
Start Date:2004End Date:2004
Investigator Status:Co-Investigator
Co-Investigators:Choo-Smith, L-P, Leonardi, L, Hewko, M, Dong, C and Williams, P