Lee, Song

Phone: (902) 494-8799

Email: Song.Lee@Dal.Ca

Professor, Department of Applied Oral Sciences

Academic Credentials:
BSc (Guelph), PhD (Guelph)
Professional Appointments:
Joint Appointment: Department of Microbiology & Immunology, Faculty of Medicine
Personal Website:



Research Interests:

Dr. Lee's laboratory is investigating the use of Streptococcus gordonii as a live oral vaccine vehicle. The goal is to achieve a protective immune response through oral colonization. In collaboration with Dr. Scott Halperin, we are investigating the use of the recombinant S. gordonii to generate a live oral vaccine against childhood diseases, such as pertussis. In addition, novel platforms for the development of single-dose vaccines for neonates are pursued with collaborators from other universities and industries.

A second focus in Dr. Lee's laboratory is investigating host-S. gordonii interactions and factors regulating antigen production in S. gordonii. The goal is to understand the recognition of S. gordonii by the host cells and the “bottle-neck” of foreign protein production to provide means to generate an efficient vaccine vehicle.

Dr. Lee’s laboratory is also interested in other oral bacteria including periodontal pathogens. Mechanisms used by Streptococcus mutans to modulate the cell surface are studied. The pathogenesis of and immunity to Treponema denticola are investigated in animal models.

Research Projects:

Functional analysis of thiol-disulfide oxidoreductases in Streptococcus gordonii
Funding Agency:NSERC Discovery
Start Date:2013End Date:2018
Investigator Status:Principal Investigator
Link:http://www.dal.ca/faculty/dentistry/news-events/news/2013/05/07/dr__song_lee_awarded_discovery_grant.html
Stainless Steel Crown Study
Funding Agency:Faculty of Dentistry Research Activity Support Fund
Start Date:2014End Date:2014
Investigator Status:Co-Investigator
Co-Investigators:R Anderson (PI), T Doyle
Further characterization of single chain antibodies against Fusobacterium nucleatum
Funding Agency:Faculty of Dentistry Research Fund
Start Date:2012End Date:2013
Investigator Status:Principal Investigator
Cell surface modulation in oral streptococci
Funding Agency:NSERC Discovery Grant
Start Date:2011End Date:2012
Investigator Status:Principal Investigator
Cell surface modulation in Streptococcus mutans
Funding Agency:NSERC Discovery Grant
Start Date:2005End Date:2010
Investigator Status:Principal Investigator
Linking innate and specific immunity to develop single dose vaccines for neonates
Funding Agency:The Gates Foundation Grand Challenges in Global Health
Start Date:2005End Date:2010
Investigator Status:Co-Investigator
Co-Investigators:L. Babiuk (PI)
Use of Streptococcus gordonii as a live oral vaccine vehicle
Funding Agency:CIHR Operating Grant, Regional Partnership Program
Start Date:2006End Date:2009
Investigator Status:Principal Investigator
Establishment of a mouse model of Treponema denticola infection
Funding Agency:Faculty of Dentistry Research Fund
Start Date:2007End Date:2008
Investigator Status:Principal Investigator
Co-Investigators:C. Marquez
Establishment of the Canadian Centre of Vaccinology (Halifax)
Funding Agency:Canadian Foundation for Innovation and CFI Research Hospital Fund
Start Date:2004End Date:2008
Investigator Status:Co-Investigator
Co-Investigators:S. Halperin (PI)
Innovative vaccine development and delivery to induce mucosal immunity
Funding Agency:CIHR Health Research Programs of Excellence Grant
Start Date:2002End Date:2007
Investigator Status:Co-Investigator
Co-Investigators:L. Babiuk (PI)