Lee, Song

Phone: (902) 494-8799

Email: Song.Lee@Dal.Ca

Professor, Department of Applied Oral Sciences

Academic Credentials:
BSc (Guelph), PhD (Guelph)
Professional Appointments:
Joint Appointment: Department of Microbiology & Immunology, Faculty of Medicine
Personal Website:



SF Lee, M Hulbah, and SA Halperin. 2016. Development of gene delivery system in Streptococcus gordonii using thymidylate synthase as a selection marker. Journal of Microbial Methods. 125:43-8.
LA Davey, J Cohen, J LeBlanc, SA Halperin, and SF Lee. 2016. The disulfide oxidreductase SdbA is active in Streptococcus gordonii using a single C-terminal cysteine of the CXXC motif. Molecular Microbiology. 99(2):236-53.
L Davey, SA Halperin, and SF Lee. 2015. Mutation of the thiol-disulfide oxidoreductase SdbA activates the CiaRH two-component system leading to bacteriocin expression shutdown in Streptococcus gordonii. Journal of Bacteriology 198(2):321-31.
A Davey, SA Halperin, and SF Lee. 2015. Immunoblotting conditions for small peptides from streptococci. Journal of Microbiology Methods. 114:40-42.
Seneviratne CJ, Leung KC, Wong CH, Lee SF, Li X, Leung PC, Lau CB, Wat E, Jin L. Nanoparticle-encapsulated chlorhexidine against oral bacterial biofilms. PLoS One. 2014 Aug 29;9(8):e103234. doi: 10.1371/journal.pone.0103234. eCollection 2014. PubMed PMID: 25170958; PubMed Central PMCID: PMC4149348.
Gao, Z., G. Qi, S. Lee, J. Li, X. Zhou, J. Wu, and X. Zha. 2013. WH1fungin a surfactin cyclic lipopeptide is a novel oral immunoadjuvant. Vaccine. 31:2796-.2803
Davey, L., C. Ng, S.A. Halperin, and S.F. Lee. 2013. Functional analysis of paralogous thiol-disulfide oxidoreductases in Streptococcus gordonii. J. Biol. Chem. 288:16416-16429
Andrian, E., G. Qi, J. Wang., S.A. Halperin, and S.F. Lee. 2013. Role of surface proteins SspA and SspB of Streptococcus gordonii in innate immunity. Microbiology 158:2099-2106.
Xu, H.L., O. Taiwo, S. Mughal, and S.F. Lee. 2013. Isolation and characterization of an antibacterial biflavonoid from an Africa chewing stick, Garcinia kola. J. Ethnopharmacol. 147:497-502.
Brown, T.H.T, J. David, E. Acosta-Ramirez, J. M. Moore, S. Lee, G. Zhong, R.E.W. Hancock, Z. Xing, S.A. Halperin, and J. Wang.. 2012. Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection. Vaccine 30:350-360.
McCormick, N. E., S.A. Halperin, and S.F. Lee. 2011. Regulation of D-alanylation of lipoteichoic acid in Streptococcus gordonii. Microbiology. 157:2248-2256
Davis, E.M., D. Kennedy, S.A. Halperin, and S.F. Lee. 2011. Role of cell wall microenvironment in the expression of heterologous SpaP/S1 protein by Streptococcus gordonii. Appl. Emviron. Microbiol. 77:1660-1666
Lee, S .F., Y .J. Li, and S .A. Halperin. 2009. Overcoming codon-usage bias in heterologous protein expression in Streptococcus gordonii. Microbiology 155:3581-3588.
Tremblay, Y .N., H. Lo, Y .H. Li, S .A. Halperin, and S .F. Lee. 2009. Expression of the Streptococcus mutans essential two-component regulatory system VicRK is pH and growth-phase dependent and controlled by the LiaFSR three-component regulatory system. Microbiology, 155:2856.
Kindrachuk, J., H. Jenssen, M. Elliott, R. Townsend, A. Nijnik, S.F. Lee, V. Gerdts, L.A. Babiuk, S.A. Halperin and R.E.W. Hancock. 2009. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine, 27:4662-4671.
Mayer, M.L., C . M. Phillips, A. Stadnyk, S .A. Halperin, and S .F. Lee. 2009. Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumor necrosis factor. Mol. Immunol. 46:883-1891.
Mayer, M.L.,C. M. Phillips, R.A.Townsend, S .A. Halperin, and S .F. Lee. 2009. Differential activation of dendritic cells by toll-like receptor agonists isolated from the Gram-positive vaccine vector Streptococcus gordonii. Scand. J. Immunol. 69:351-356.
Lee, S .F., E. Andrian, E. Rowland, and I. C. Marquez. 2009. Immune response and alveolar bone resorption in a mouse model of Treponema denticola infection. Infect. Immun.77:694-698.